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An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
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Testing and Scaling Interventions to Improve the Tuberculosis Infection Care Cascade
Jeffrey I Campbell1, Dick Menzies2
1Division of Infectious Diseases, Boston Children's Hospital, Boston, Massachusetts, USA.
Journal of the Pediatric Infectious Diseases Society
|October 31, 2022
Summary
Tuberculosis preventive therapy (TPT) is crucial for children, but barriers hinder its scale-up. Addressing gaps in the care cascade using new and old tools is vital for global tuberculosis elimination efforts.
Area of Science:
- Public Health
- Infectious Diseases
- Pediatrics
Background:
- Tuberculosis preventive therapy (TPT) is essential for global tuberculosis elimination, especially for children at high risk.
- Barriers significantly impede the successful scale-up and delivery of TPT to eligible individuals.
- The cascade of care framework helps evaluate and improve TPT provision for TB infection and contact management.
Conclusions:
- Closing care cascade gaps is critical for effective TPT scale-up.
- A multi-faceted approach integrating new and existing tools is required.
- Enhanced collaboration and innovative strategies are necessary for global TB elimination, particularly for vulnerable pediatric populations.
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