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Related Concept Videos

Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...

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Determining Gender-Based Differences in Retinal and Choroidal Thickness in Underweight Individuals via Swept-Source Optical Coherence Tomography
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Association Between Optical Coherence Tomography Angiography Findings and Inner Retinal Thickness in Diabetic

Emine Temel1, Sibel Demirel1, Figen Batıoğlu1

  • 1Ankara University Faculty of Medicine, Department of Ophthalmology, Ankara, Turkey.

Turkish Journal of Ophthalmology
|November 1, 2022
PubMed
Summary

Diabetic patients, with or without retinopathy, have thinner inner retinas compared to controls. Optical coherence tomography angiography (OCTA) findings correlate with inner retinal thickness (IRT), indicating microvascular and neurodegenerative changes in diabetes.

Keywords:
Diabetic retinopathyinner retinal thicknessoptical coherence tomography angiography

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Area of Science:

  • Ophthalmology
  • Diabetic Retinopathy Research
  • Medical Imaging

Background:

  • Diabetic retinopathy (DR) is a leading cause of vision loss.
  • Inner retinal thickness (IRT) and foveal avascular zone (FAZ) are key indicators of retinal health.
  • Optical coherence tomography angiography (OCTA) provides detailed microvascular imaging.

Purpose of the Study:

  • To investigate the association between OCTA findings and IRT in diabetic patients.
  • To compare these metrics in diabetic patients with and without retinopathy against non-diabetic controls.

Main Methods:

  • Retrospective study of 23 eyes with DR, 30 eyes with diabetes but no DR, and 27 non-diabetic controls.
  • OCTA imaging (6x6 mm) to measure FAZ area, parafoveal vessel density, and parafoveal IRT.
  • Statistical analysis to determine correlations between IRT and OCTA parameters.

Main Results:

  • Diabetic patients (with and without DR) had significantly thinner IRT compared to controls (p<0.014).
  • FAZ area was significantly larger in diabetic groups compared to controls (p<0.001).
  • IRT was negatively correlated with FAZ area in both diabetic groups (r=-0.320 and -0.512).

Conclusions:

  • Diabetic patients exhibit reduced inner retinal thickness and altered FAZ, regardless of retinopathy status.
  • OCTA-derived microvascular changes correlate with IRT changes in diabetes.
  • OCTA may detect early microvascular and neurodegenerative changes preceding visible retinopathy.