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Updated: Aug 23, 2025

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
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Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells

Published on: April 26, 2017

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ASCancer Atlas: a comprehensive knowledgebase of alternative splicing in human cancers

Song Wu1,2, Yue Huang3,2, Mochen Zhang1,2

  • 1National Genomics Data Center & CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China.

Nucleic Acids Research
|November 1, 2022
PubMed

Insights

Alternative splicing (AS) dysregulation drives cancer. The ASCancer Atlas integrates 2006 experimentally validated cancer-associated splicing events and millions of putative events, offering a crucial resource for understanding cancer progression and developing therapies.

Area of Science:

  • Molecular Biology
  • Genomics
  • Bioinformatics

Background:

  • Alternative splicing (AS) is crucial for cellular functions.
  • Dysregulated AS contributes to cancer initiation, progression, and treatment resistance.
  • A comprehensive resource for cancer-associated splicing events is lacking.

Purpose of the Study:

  • To develop a comprehensive knowledgebase of aberrant splicing in human cancers.
  • To integrate cancer-associated splicing changes for understanding their functional consequences.
  • To provide a resource for studying splicing dysregulation in human cancers.

Main Methods:

  • Development of the ASCancer Atlas knowledgebase.
  • Curated collection of 2006 experimentally validated cancer-associated splicing events.
  • Inclusion of a splicing regulatory network and computational putative events.
  • Creation of a user-friendly web interface for data access and analysis.

Main Results:

  • ASCancer Atlas houses 2006 high-confidence, experimentally validated cancer-associated splicing events.
  • The resource includes a systematic splicing regulatory network.
  • It contains approximately 2 million computationally putative splicing events.
  • Detailed functional information (regulators, effects, therapeutics) is curated for each event.

Conclusions:

  • ASCancer Atlas is a unique and comprehensive resource for aberrant splicing in human cancers.
  • It facilitates the study of functional roles and therapeutic strategies related to splicing dysregulation.
  • The knowledgebase aids in understanding the cross-talk and consequences of cancer-associated splicing changes.

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