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HERBAL MEDICINES ANTIMICROBIAL EFFECT
O Gancho1, T Moshel1, O Boychenko1
1Poltava State Medical University, Ukraine.
Georgian Medical News
|November 1, 2022
Summary
This study compared the antimicrobial activity of herbal medicines against standard microbial strains. Tymsal, panavir, and proteflazid demonstrated superior efficacy compared to traditional drugs, showing significant sensitivity in various microorganisms.
Area of Science:
- Microbiology
- Pharmacology
- Natural Products
Background:
- Antimicrobial resistance necessitates exploring novel therapeutic agents.
- Herbal medicines offer a potential alternative to conventional antibiotics.
- Evaluating the efficacy of specific herbal compounds against common pathogens is crucial.
Purpose of the Study:
- To assess and compare the antimicrobial sensitivity of standard microbial strains to selected herbal medicines.
- To determine the efficacy of herbal medicines like tymsal, panavir, and proteflazid against bacteria and fungi.
- To compare the antimicrobial activity of herbal medicines with standard antimicrobial drugs.
Main Methods:
- Utilized standard microbial strains including Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Escherichia coli, and Candida albicans.
- Employed the disk diffusion method and serial dilutions method for antimicrobial susceptibility testing, adhering to European Committee on Antimicrobial Susceptibility Testing (EUCAST) guidelines.
- Quantified microbial sensitivity through zone of inhibition measurements and determination of minimum inhibitory concentrations.
Main Results:
- Escherichia coli exhibited maximum sensitivity to tymsal.
- Enterococcus faecalis strains demonstrated statistically significant sensitivity exclusively to panavir.
- Candida albicans showed enhanced sensitivity to proteflazid, with fungicidal activity 1.2 times greater than chlorhexidine.
- Staphylococcus epidermidis displayed 2.17 times greater sensitivity to tymsal compared to the chlorhexidine control.
Conclusions:
- Herbal medicines tymsal, panavir, and proteflazid exhibit significant antimicrobial activity against tested microorganisms.
- These herbal formulations show comparable or superior efficacy to conventional antimicrobial agents.
- Further research into these herbal medicines could lead to novel therapeutic strategies for infectious diseases.
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