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PNEUMONIA AMONG CHILDREN UNDER 1 YEAR OF AGE: ANALYSIS OF INCIDENCE AND HOSPITAL MORTALITY FROM 2010 TO 2020 IN THE
L Yeraliyeva1, A Issayeva2, G Tanbayeva3
1NJSC "National Medical University" named after S.D. Asfendiyarov, Almaty, Republic of Kazakhstan; "National Scientific Center for Phthisiopulmonology" of the Ministry of Health of the Republic of Kazakhstan, Almaty, Republic of Kazakhstan; NJSC "Al-Farabi Kazakh National University", Almaty, Republic of Kazakhstan.
Insights
Pneumonia incidence in Kazakhstan children under 1 decreased significantly after pneumococcal vaccination was introduced. Further study on vaccination refusals is recommended.
Area of Science:
- Pediatrics
- Epidemiology
- Public Health
Background:
- Pneumonia remains a leading cause of child mortality globally.
- The introduction of pneumococcal conjugate vaccines (PCVs) has shown promise in reducing pneumonia burden.
- Kazakhstan introduced PCV into its National Immunization Schedule in 2010.
Purpose of the Study:
- To analyze the trends in pneumonia morbidity and mortality among children under 1 year of age in Kazakhstan.
- To evaluate the impact of the national pneumococcal vaccination program over a 10-year period (2010-2020).
Main Methods:
- Retrospective cross-sectional study design.
- Utilized statistical data from the National Scientific Center for Health Development (2010-2020).
- Epidemiological analysis focused on pneumonia incidence per 1000 children under 1 year.
Main Results:
- Pneumonia incidence in children under 1 decreased from 54.1 cases per 1000 in 2010 to 20.1 cases per 1000 in 2020.
- Regional analysis identified specific areas with persistently high pneumonia incidence.
- While overall incidence declined, Almaty showed a relatively high proportion of mortality from all causes in infants.
Conclusions:
- The national immunization program against pneumococcal infection has been associated with a significant reduction in pneumonia incidence in infants in Kazakhstan.
- Despite the overall decrease, regional disparities and specific mortality patterns warrant further investigation.
- Future research should explore factors influencing vaccine uptake, including parental refusal rates.
Abstract:
Aim - to analyze the dynamics of morbidity and mortality from pneumonia in children under 1 year of age in the Republic of Kazakhstan for 10 years since the introduction of vaccination against pneumococcal infection in the National Immunization Schedule of the Republic of Kazakhstan in 2010. A retrospective cross-sectional study was carried out using the statistical collection of the National Scientific Center for Health Development named after S. Kairbekova from 2010 to 2020. The criterion for the study of epidemiology was the incidence of pneumonia in children under 1 year of age per 1000 children. The indicator compared with 2010 in the year, the incidence decreased by 34.0 cases, and amounted to 20.1 cases. In 2010, it was 54.1 cases. Analyzing the lethality of children from pneumonia by region, we also decided to show the top 5 regions with a high rate. This list in 2010 included Akmola (n=149.7), Turkestan (n=79.7), West Kazakhstan (n=76.9), Kostanay regions (n=66.1) and the city of Nur-Sultan (until 2019, the city of Astana) (n=69.5). The indicator for the republic in 2010 was 54.1 cases per 1,000 children. The incidence per 1000 children in 6 regions and 1 city is higher than the republican indicator. In 2020, in Kazakhstan, the incidence of pneumonia in children under 1-year-old per 1000 children was 20.1 cases. In such regions as Akmola, Turkestan, North Kazakhstan, Kostanay and Zhambyl regions, the indicators are the highest in the country. From 2010 to 2020, the incidence of pneumonia in children under 1 year of age tends to decrease in Kazakhstan, however, the city of Almaty shows a relatively high proportion of the total mortality for all diseases under 1 year of age. This work is analytical, and further work with a study of immunization of children against pneumococcal infection is required for a full study. A curve should be plotted on parental refusals to vaccinate over a given period of time.
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