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Updated: Aug 23, 2025
Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
Scalemic myrionsumamide A, tetracyclic skeleton alkaloids from Myrioneuron effusum
Jia-Hui Zhang1,2, Mingming Cao1, Yu Zhang1
1State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences Kunming 650201 China haoxj@mail.kib.ac.cn diyt@mail.kib.ac.cn.
Abstract:
Investigation of the alkaloids from Myrioneuron effusum leads to the isolation of myrionsumamide A (1), a pair of enantiomeric alkaloids with an unprecedented tetracyclic system skeleton. These two alkaloids were separated by chiral HPLC with a ratio of 3 : 5 from the scalemic mixture. Their structures including absolute configurations were determined by NMR spectroscopy, X-ray diffraction data and ECD calculations. Both (+)-1 and (-)-1 showed antibacterial activity against Staphylococcus aureus with MIC at 7.81 μg ml-1.
