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Stable and reusable Ni-based nanoparticles for general and selective hydrogenation of nitriles to amines

Zhuang Ma1, Vishwas G Chandrashekhar1, Bei Zhou1

  • 1Leibniz-Institut für Katalyse e.V. Albert-Einstein-Str. 29a Rostock D-18059 Germany matthias.beller@catalysis.de jagadeesh.rajenahally@catalysis.de.

Chemical Science
|November 2, 2022
PubMed

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Nitriles can be reduced to primary amines using reducing agents like lithium aluminum hydride or catalytic hydrogenation. The reduction introduces an amino group with an extra carbon in the skeleton. Nitriles are formed from the reaction between alkyl halides and sodium cyanide through the SN2 mechanism. Primary alkyl halides are the preferred substrates to prepare nitriles.
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