Novel intraoperative strategies for enhancing tumor control: Future directions
Alexander F Haddad1, Manish K Aghi1, Nicholas Butowski1
1Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
Abstract:
Maximal safe surgical resection plays a key role in the care of patients with gliomas. A range of technologies have been developed to aid surgeons in distinguishing tumor from normal tissue, with the goal of increasing tumor resection and limiting postoperative neurological deficits. Technologies that are currently being investigated to aid in improving tumor control include intraoperative imaging modalities, fluorescent tumor makers, intraoperative cell and molecular profiling of tumors, improved microscopic imaging, intraoperative mapping, augmented and virtual reality, intraoperative drug and radiation delivery, and ablative technologies. In this review, we summarize the aforementioned advancements in neurosurgical oncology and implications for improving patient outcomes.
Insights
Maximizing safe surgical removal of gliomas is crucial. New technologies are emerging to help surgeons better differentiate tumor from healthy tissue, improving resection and reducing patient deficits.
Area of Science:
- Neurosurgical Oncology
- Medical Technology
Background:
- Maximal safe surgical resection is fundamental for glioma patient care.
- Distinguishing tumor from normal tissue is critical to improve resection rates and minimize postoperative neurological deficits.
Approach:
- This review summarizes advancements in neurosurgical oncology technologies.
- Investigated technologies include intraoperative imaging, fluorescent markers, molecular profiling, advanced microscopy, mapping, AR/VR, and targeted drug/radiation delivery.
Key Points:
- Novel technologies aim to enhance tumor visualization and characterization during surgery.
- These advancements support more precise tumor resection and personalized treatment strategies.
- Integration of diverse technologies offers potential for improved glioma control.
Conclusions:
- Emerging technologies in neurosurgical oncology show promise for improving patient outcomes.
- Enhanced intraoperative capabilities can lead to more effective glioma treatment.
- Continued research and development are vital for advancing neurosurgical oncology.
