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Updated: Aug 23, 2025

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

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Giant cell arteritis in the elderly

Abrar-Ahmad Zulfiqar1, Marine Richard2, Carl Arndt3

  • 1Département de médecine interne, diabète et maladies métaboliques, Clinique médicale B, Hôpitaux universitaires de Strasbourg, Strasbourg, France

Geriatrie Et Psychologie Neuropsychiatrie Du Vieillissement
|November 2, 2022
PubMed

Insights

Giant cell arteritis (GCA) outcomes show no significant differences between patients aged 75 or younger and those older than 75. However, aortitis was less prevalent in older patients, who also had shorter follow-up periods.

Area of Science:

  • Rheumatology
  • Vascular Medicine
  • Geriatric Medicine

Context:

  • Giant cell arteritis (GCA), also known as Horton’s disease, is an inflammatory condition affecting large and medium-sized arteries.
  • It predominantly affects individuals aged 50 and older, with a peak incidence between 70 and 80 years.
  • Limited clinical data exists for GCA patients over 80 years old.

Purpose:

  • To evaluate and compare the impact of age on the diagnosis, treatment, and prognosis of GCA.
  • To analyze differences in GCA presentation and outcomes between patients aged 75 or younger and those older than 75.

Summary:

  • A retrospective study of 67 GCA patients (2012-2017) divided them into two age groups: ≤75 and >75 years.
  • No statistically significant differences in mortality or overall outcomes were observed between the age groups.
  • Aortitis was less common in patients over 75, while those 75 or younger experienced more relapses, potentially due to shorter follow-up.

Impact:

  • This study provides insights into GCA management in elderly populations.
  • Findings suggest age itself may not be a critical prognostic factor, but specific manifestations like aortitis may differ.
  • Highlights the need for tailored follow-up strategies considering potential differences in disease presentation and relapse rates.
Abstract

Keywords:
Horton diseaseGiant cell arteritiselderly patientsdiagnosistreatmentprognosisaortitisrelapses

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