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Are cortical microvascular raspberries caused by cerebral hypoperfusion? An exploratory pathological study
Henric Ek Olofsson1, Mattias Haglund1, Elisabet Englund1
1Division of Pathology, Department of Clinical Sciences Lund, Lund University, Sölvegatan 25B, 22185 Lund, Sweden.
Cerebral Circulation - Cognition and Behavior
|November 3, 2022
Summary
Cortical raspberries, a microvascular formation, were studied in relation to cerebral atherosclerosis. Higher raspberry density was significantly associated with cerebral atherosclerosis in this exploratory study.
Area of Science:
- Neuropathology
- Cerebrovascular Research
- Angiogenesis
Background:
- Cortical microvascular formations, termed 'raspberries,' were observed.
- The study investigated the hypothesis that raspberry formation is an angiogenic process linked to cerebral hypoperfusion.
Purpose of the Study:
- To explore the association between cortical raspberry formation and various clinical and pathological factors.
- Specifically, to determine if raspberry density correlates with cerebral atherosclerosis.
Main Methods:
- Retrospective analysis of 62 deceased individuals' neuropathological samples.
- Manual quantification of raspberry density in haematoxylin and eosin-stained anterior frontal lobe sections.
- Comparison of raspberry density with clinical data including age, sex, hypertension, diabetes, and cerebrovascular conditions.
Main Results:
- A statistically significant higher density of cortical raspberries was observed in subjects with cerebral atherosclerosis (p=0.029).
- This association remained significant in multiple linear regression analysis (p=0.003).
- No significant associations were found for other investigated variables, suggesting an exploratory nature of these findings.
Conclusions:
- Cortical raspberries may be associated with cerebral atherosclerosis.
- Further research is warranted to explore potential links with other factors like acute circulatory failure.
