Immunogenicity of the BA.5 Bivalent mRNA Vaccine Boosters
Ai-Ris Y Collier1, Jessica Miller1, Nicole P Hachmann1
1Beth Israel Deaconess Medical Center, Boston, MA, USA.
Biorxiv : the Preprint Server for Biology
|November 3, 2022
Abstract:
Waning immunity following mRNA vaccination and the emergence of SARS-CoV-2 variants has led to reduced mRNA vaccine efficacy against both symptomatic infection and severe disease. Bivalent mRNA boosters expressing the Omicron BA.5 and ancestral WA1/2020 Spike proteins have been developed and approved, because BA.5 is currently the dominant SARS-CoV-2 variant and substantially evades neutralizing antibodies (NAbs). Our data show that BA.5 NAb titers were comparable following monovalent and bivalent mRNA boosters.
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