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Related Experiment Videos

Chronic nephritis in a horse.

R G Alders, D R Hutchins

    Australian Veterinary Journal
    |May 1, 1987
    PubMed
    Summary

    This study details a case of end-stage renal disease in an 11-year-old Anglo-Arabian mare. The horse experienced chronic weight loss and inappetence, ultimately diagnosed through necropsy and histopathology.

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    Area of Science:

    • Veterinary Medicine
    • Nephrology
    • Equine Health

    Background:

    • Progressive weight loss and inappetence are common presenting signs in horses.
    • Primary renal failure can manifest with non-specific clinical signs, complicating early diagnosis.
    • End-stage renal disease (ESRD) represents advanced kidney damage with significant implications for animal health.

    Observation:

    • An 11-year-old Anglo-Arabian mare presented with a five-month history of gradual weight loss and inappetence.
    • Physical examination revealed fair body condition without localizing signs of illness.
    • Laboratory results showed persistently elevated blood urea nitrogen and isothenuria, indicative of renal dysfunction.

    Findings:

    • Necropsy confirmed shrunken and contracted kidneys.
    • Histopathological examination revealed severe and diffuse interstitial fibrosis.
    • These lesions were consistent with end-stage renal disease.

    Implications:

    • This case highlights the importance of considering renal failure in horses with chronic, non-specific signs.
    • Early diagnostic indicators like elevated blood urea nitrogen and isothenuria are crucial for identifying renal disease.
    • Understanding the pathological characteristics of ESRD in horses aids in diagnosis and prognosis.

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