Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

70
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
70
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

53
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
53
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

56
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
56
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

62
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
62
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

65
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
65
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

55
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
55

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Trends in Nephrology: from treating kidney disease to maintaining kidney health.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026
Same author

Environmental footprint of peritoneal dialysis in Europe: a comparative life cycle assessment across four European centres.

Clinical kidney journal·2026
Same author

Sex, menopause and chronic kidney disease in primary care.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026
Same author

ATTR: the forgotten kidney amyloidosis.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026
Same author

Optimization of artificial intelligence models for prediction of new-onset cardiovascular disease in patients with arterial hypertension.

PLOS digital health·2026
Same author

Prevalence of Hyperkalemia in a Contemporary European Cohort According to EKFC eGFR Categories.

Diagnostics (Basel, Switzerland)·2026

Related Experiment Video

Updated: Aug 23, 2025

Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection
10:15

Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection

Published on: November 10, 2021

1.9K

Probiotics for kidney disease.

Chiara Favero1, Alberto Ortiz1,2, Maria D Sanchez-Niño1,3

  • 1Laboratorio de Nefrología Experimental, Instituto de Investigación Sanitaria-Fundacion Jimenez Diaz, Universidad Autonoma de Madrid, Madrid, Spain.

Clinical Kidney Journal
|November 3, 2022
PubMed
Summary
This summary is machine-generated.

Diet significantly impacts kidney disease, influencing gut microbiota and its metabolites. A probiotic, Lactobacillus casei Zhang, shows potential in protecting against acute kidney injury and chronic kidney disease progression.

Keywords:
acute kidney injurybutyratechronic kidney diseasefibrosisinflammationmicrobiotanicotinamideprobioticshort-chain fatty acids

More Related Videos

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

271
Robot-Assisted Kidney Transplantation
07:30

Robot-Assisted Kidney Transplantation

Published on: July 19, 2021

3.7K

Related Experiment Videos

Last Updated: Aug 23, 2025

Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection
10:15

Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection

Published on: November 10, 2021

1.9K
Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

271
Robot-Assisted Kidney Transplantation
07:30

Robot-Assisted Kidney Transplantation

Published on: July 19, 2021

3.7K

Area of Science:

  • Nephrology
  • Microbiology
  • Nutritional Science

Background:

  • Diet profoundly affects kidney health, influencing both acute kidney injury (AKI) and chronic kidney disease (CKD).
  • Dietary components can directly impact the body or modulate gut microbiota composition and its metabolites, thereby influencing kidney disease.
  • The interplay between diet, gut microbiota, and kidney disease necessitates research into microbiota-targeted interventions for CKD management.

Discussion:

  • Interventions like probiotics, prebiotics, and fecal microbiota transplantation aim to modify the gut microbiota and its metabolome for treating CKD.
  • Lactobacillus casei Zhang, a probiotic from traditional Chinese koumiss, has demonstrated protective effects against AKI and CKD in mice.
  • This probiotic may slow CKD progression in humans by modulating gut microbiota, increasing beneficial short-chain fatty acids, and enhancing nicotinamide availability.

Key Insights:

  • Lactobacillus casei Zhang emerges as a potential probiotic intervention for AKI and CKD.
  • Mechanisms involve gut microbiota modulation, increased anti-inflammatory short-chain fatty acids, and nicotinamide production.
  • The study highlights the critical role of the gut microbiome in kidney disease pathogenesis and treatment.

Outlook:

  • Further large-scale, well-designed clinical trials are essential to validate the clinical relevance and efficacy of Lactobacillus casei Zhang in human CKD.
  • Exploring the specific metabolites and microbial pathways influenced by this probiotic could refine therapeutic strategies.
  • Investigating the long-term effects and optimal dosage of Lactobacillus casei Zhang in CKD patients is crucial for its therapeutic application.