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Cardiovascular response to sudden strenuous exercise.

H W Duncan, R J Barnard, G K Grimditch

    Basic Research in Cardiology
    |May 1, 1987
    PubMed
    Summary
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    Sudden strenuous exercise initially decreases myocardial oxygen delivery due to reduced coronary blood flow, creating an imbalance with rapidly increasing oxygen demand. This occurs before metabolic regulation can increase blood flow to meet exercise needs.

    Area of Science:

    • Cardiovascular Physiology
    • Exercise Physiology
    • Myocardial Metabolism

    Background:

    • Sudden strenuous exercise imposes rapid demands on the cardiovascular system.
    • Understanding the immediate cardiac and coronary blood flow responses is crucial for exercise physiology.
    • Myocardial oxygen supply-demand balance is critical during physical exertion.

    Purpose of the Study:

    • To investigate the acute cardiac and coronary blood flow responses in dogs during sudden strenuous exercise.
    • To determine the timing of myocardial oxygen supply and demand imbalance.
    • To elucidate the role of coronary blood flow regulation in this imbalance.

    Main Methods:

    • Seven dogs were instrumented to measure cardiac output (Q), stroke volume (SV), left ventricular (LV) pressure, aortic pressure, and circumflex coronary blood flow (CBF).

    Related Experiment Videos

  • Dogs performed sudden strenuous exercise on a treadmill (12.9 km/h, 20% grade) for 15 seconds without warm-up.
  • Myocardial oxygen requirements were estimated using the tension-time index (TTI) or calculated wall tension.

    • Main Results:

    • Heart rate (HR) and cardiac output (Q) increased rapidly within the first 10 seconds.
    • Myocardial oxygen requirements significantly increased by 2 seconds.
    • Mean coronary blood flow (CBF) decreased by 13% and stroke CBF by 49% at 2 seconds, preceding increases in LV dP/dt and SV.
    • Stroke CBF did not recover to resting levels, and mean CBF continued to increase until exercise termination.

    Conclusions:

    • Sudden strenuous exercise causes a transient mismatch between myocardial oxygen supply and demand.
    • This imbalance is driven by an initial decrease in coronary blood flow.
    • Delayed metabolic regulation of coronary blood flow contributes to the transient supply-demand deficit.