Related Experiment Video

Updated: Aug 23, 2025

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
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Published on: January 22, 2018

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[Advances in Treatment of Human Epidermal Growth Factor Receptor 2-Positve Gastric Cancer]

Xiao-Qian Wu1, Yu-Ping Ge1, Xiao-Lei Gong1

  • 1Department of Medical Oncology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
|November 3, 2022
PubMed

Insights

Human epidermal growth factor receptor 2 (HER2)-positive gastric cancer treatment has advanced with trastuzumab and pembrolizumab therapies. Research continues to address resistance and explore novel HER2-targeted drugs for improved patient outcomes.

Area of Science:

  • Oncology
  • Gastroenterology
  • Pharmacology

Background:

  • Gastric cancer is a leading cause of cancer mortality globally.
  • HER2-positive gastric cancer, a subtype, benefits from trastuzumab combined with chemotherapy.
  • Pembrolizumab plus chemotherapy represents a first-line standard for HER2-positive gastric cancer, improving response rates.

Conclusions:

  • Advances in HER2-targeted therapy offer improved treatment options for gastric cancer.
  • Ongoing research into novel HER2 drugs and resistance mechanisms is crucial.
  • Personalized treatment strategies are essential for optimizing outcomes in HER2-positive gastric cancer.
Keywords:
gastric cancerhuman epidermal growth factor receptor 2targeted therapy

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