Non-coding RNA and their potential role in cardiovascular diseases

Area of Science:

• Biochemistry
• Molecular Biology
• Genetics

Background:

• Cardiovascular diseases (CVDs) represent a major global health burden and mortality cause.
• Early diagnosis of CVDs remains a significant clinical challenge.
• Non-coding RNAs, once dismissed as 'junk DNA,' are now recognized for their critical regulatory roles in CVDs and as potential therapeutic targets.

Purpose of the Study:

• To review the significant roles of non-coding RNAs in the pathogenesis and progression of cardiovascular diseases.
• To highlight the potential of non-coding RNAs as biomarkers for early CVD diagnosis.
• To introduce databases that aid in the experimental analysis of non-coding RNAs.

Main Methods:

• Comprehensive literature search conducted on PubMed and SCOPUS.
• Keywords included "non-coding RNAs," "coronary artery disease," "miRNAs," "myocardial infarction," and "cardiovascular diseases."
• No date restrictions were applied to the literature search for this review.

Main Results:

• Non-coding RNAs, including microRNAs (miRNAs), play multifaceted roles in cardiovascular regulation and disease.
• Dysregulation of specific non-coding RNAs is implicated in conditions like coronary artery disease and myocardial infarction.
• Databases facilitating non-coding RNA analysis can accelerate research and discovery.

Conclusions:

• Non-coding RNAs are emerging as key players in cardiovascular disease, offering novel avenues for diagnosis and treatment.
• Further research into non-coding RNA function and therapeutic application is warranted.
• Utilizing specialized databases can enhance the efficiency and accuracy of non-coding RNA research in cardiovascular medicine.