Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Response01:28

Inflammatory Response

4.9K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
4.9K
Inflammation01:38

Inflammation

54.4K
Overview
54.4K
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

12.0K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
12.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The next generation of alginate dressings: recent innovations for chronic wound healing.

Regenerative biomaterials·2026
Same author

Beyond first responders: neutrophils shape biomaterial-guided regeneration.

Biomaterials science·2026
Same author

The Role of Neutrophils in Biomaterial-Based Tissue Repair-Shifting Paradigms.

Journal of functional biomaterials·2023
Same author

The Use of Specialized Pro-Resolving Mediators in Biomaterial-Based Immunomodulation.

Journal of functional biomaterials·2023
Same author

Chitosan 3D scaffolds with resolvin D1 for vertebral arthrodesis: a pilot study.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2023
Same author

Immunomodulatory biomaterial-based wound dressings advance the healing of chronic wounds via regulating macrophage behavior.

Regenerative biomaterials·2022

Related Experiment Video

Updated: Aug 23, 2025

A Macrophage Reporter Cell Assay to Examine Toll-Like Receptor-Mediated NF-kB/AP-1 Signaling on Adsorbed Protein Layers on Polymeric Surfaces
07:55

A Macrophage Reporter Cell Assay to Examine Toll-Like Receptor-Mediated NF-kB/AP-1 Signaling on Adsorbed Protein Layers on Polymeric Surfaces

Published on: January 7, 2020

7.5K

The inflammasome in biomaterial-driven immunomodulation.

Daniela P Vasconcelos1,2, Artur P Águas3,4, Judite N Barbosa1,2,3

  • 1i3S - Instituto de Inovação e Investigação em Saúde, Universidade do Porto, Porto, Portugal.

Journal of Tissue Engineering and Regenerative Medicine
|November 3, 2022
PubMed
Summary
This summary is machine-generated.

Inflammasomes are crucial for innate immunity, responding to danger signals and activating inflammatory cytokines. Controlling inflammasome activity offers potential for regenerative medicine and biomaterial applications.

Keywords:
biomaterialimmunomodulationinflammasomeinflammationregenerative medicine

More Related Videos

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages
06:52

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages

Published on: May 21, 2018

10.8K
Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells
09:04

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells

Published on: May 22, 2014

21.0K

Related Experiment Videos

Last Updated: Aug 23, 2025

A Macrophage Reporter Cell Assay to Examine Toll-Like Receptor-Mediated NF-kB/AP-1 Signaling on Adsorbed Protein Layers on Polymeric Surfaces
07:55

A Macrophage Reporter Cell Assay to Examine Toll-Like Receptor-Mediated NF-kB/AP-1 Signaling on Adsorbed Protein Layers on Polymeric Surfaces

Published on: January 7, 2020

7.5K
Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages
06:52

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages

Published on: May 21, 2018

10.8K
Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells
09:04

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells

Published on: May 22, 2014

21.0K

Area of Science:

  • Immunology
  • Biomaterials Science
  • Regenerative Medicine

Background:

  • Inflammasomes are intracellular protein complexes vital for innate immunity.
  • They activate inflammatory caspases, leading to Interleukin (IL)-1β and IL-18 production.
  • Biomaterial implantation triggers cellular injury and danger signals, activating inflammasomes.

Purpose of the Study:

  • To review current knowledge on inflammasome involvement in the inflammatory response to biomaterials.
  • To explore the potential of inflammasome modulation in regenerative medicine.
  • To highlight the role of inflammasomes in immunomodulation related to biomaterials.

Main Methods:

  • Literature review of inflammasome function in host defense.
  • Analysis of inflammasome activation pathways in response to biomaterial implantation.
  • Synthesis of current research on inflammasomes in tissue repair and inflammation.

Main Results:

  • Inflammasomes are activated by danger signals from injured cells post-biomaterial implantation.
  • Inflammasome activation influences pathogen clearance, chronic inflammation, and tissue repair.
  • Evidence suggests inflammasomes play a role in the inflammatory response to biomaterials.

Conclusions:

  • Modulating inflammasome activity is a promising strategy for regenerative medicine.
  • Understanding inflammasome-biomaterial interactions is key for developing advanced therapies.
  • The immunomodulatory potential of inflammasomes in biomaterial applications is underexplored.