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Updated: Aug 23, 2025

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Intermediate stimulation frequencies for language mapping using Stereo-EEG.

Ginevra Giovannelli1, Veronica Pelliccia2, Belén Abarrategui3

  • 1"Claudio Munari" Epilepsy Surgery Centre, Department of Neuroscience, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy; Department of Neurology 2, Careggi University Hospital, Florence, Italy.

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
|November 3, 2022
PubMed
Summary
This summary is machine-generated.

Intermediate frequency electrical intracerebral stimulations (IFS) are effective for localizing language areas (LAs). These stimulations showed similar efficacy to high-frequency stimulations but with fewer after-discharges, aiding precise clinical testing.

Keywords:
Functional mappingIntracerebral electrical stimulationsLanguageStereo-electroencephalography

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Area of Science:

  • Neuroscience
  • Neurosurgery
  • Epileptology

Background:

  • Identifying eloquent cortices, especially language areas (LAs), is crucial for surgical planning but remains challenging.
  • Electrical intracerebral stimulations (ES) during Stereo-electroencephalography (SEEG) are vital for LA localization.
  • High-frequency ES (HFS, 50 Hz) is the current gold standard, while low frequencies (1 Hz) are ineffective.

Purpose of the Study:

  • To investigate the utility of intermediate frequency electrical stimulations (IFS) for localizing language areas (LAs).
  • To compare the efficacy and safety of IFS (6, 9, and 12 Hz) against standard HFS (50 Hz).

Main Methods:

  • An observational, prospective study was conducted involving ten patients undergoing SEEG.
  • A standardized protocol compared IFS (6, 9, 12 Hz, 15-second duration) with HFS (50 Hz).
  • Eighty-six ES were performed in identified LAs.

Main Results:

  • Sixty-one point six percent of ES in LAs resulted in language interference, with no significant difference between IFS and HFS.
  • IFS demonstrated a significantly lower incidence of after-discharges (ADs) compared to HFS (53.3% vs. 21.7%).

Conclusions:

  • Intermediate frequency stimulations (IFS) are as effective as high-frequency stimulations (HFS) for LA localization.
  • IFS exhibit a lower incidence of after-discharges and their longer duration allows for more accurate clinical testing.
  • IFS show promise as a valuable tool for studying language areas during SEEG.