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Neural Tube Closure in Mouse Whole Embryo Culture
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Fetal Repair of Neural Tube Defects

Su Yeon Lee1, Ramesha Papanna2, Diana Farmer3

  • 1Department of Surgery, Division of Pediatric, Thoracic and Fetal Surgery, University of California Davis Medical Center, 2335 Stockton Boulevard, Room 5107, Sacramento, CA 95817, USA.

Clinics in Perinatology
|November 3, 2022
PubMed

Myelomeningocele is the most common congenital neurologic defect, and the only nonlethal disease addressed by fetal surgery. A randomized control trial has established amelioration of the Arnold-Chiari II malformation, reduced ventriculoperitoneal shunt rate, and improvement in distal neurologic function in patients that receive in utero repair. Long-term follow-up of these school-age children demonstrates the persistence of these effects. The use of stem cells in fetal repair is being investigated to further improve distal motor function.

Keywords:
MOMS trialMyelomeningoceleOpen neural tube defectSpina bifida

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