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Updated: Aug 23, 2025
Tissue Engineering of the Intestine in a Murine Model
Published on: December 1, 2012
A new surgical technique for short bowel syndrome
Isamu Saeki1, Sho Kurihara2, Masato Kojima2
1Department of Pediatric Surgery, Hiroshima University Hospital, 1-2-3 Kasumi Minami-Ku, Hiroshima-Shi, Hiroshima, 734-8551, Japan. isaeki@hiroshima-u.ac.jp.
Objective:
Short bowel syndrome (SBS) is a severe intestinal disease that causes malabsorption. Long-term parental nutrition therapy induces infection and liver failure. For the surgical management of intestinal rehabilitation, the intestinal loop lengthening method and serial transverse enteroplasty (STEP) method have been reported, although their effects have proven limited. We herein report a new surgical technique, Saeki-Spiral-Shark (3S) method for SBS using biomimetics of shark intestine.
Methods:
In the 3S method, a spiral valve is formed inside the intestine by external sutures. Using a 25 cm length intestinal organ model, we performed both the 3S method and STEP procedure. We then compared the length and fluid passage times of the subsequently formed intestine.
Results:
After the 3S method was performed, the length of the intestinal model changed to 22 cm, and after the STEP procedure, that was elongated to 30 cm. Although the water passage times did not change markedly, the semi-digestive nutritional supplement passage time slowed down in the model with the 3S method. There was slight leakage in the STEP procedure model.
Conclusions:
The 3S method is a unique method of treating SBS based on biomimetics. This procedure does not require an incision of the intestine, which thereby enabling clean and less-invasive surgery. We plan to conduct animal experiments in the future.
