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Related Concept Videos

Renal Tubule and Collecting Duct01:24

Renal Tubule and Collecting Duct

1.3K
The renal tubule is divided into three parts: the proximal convoluted tubule (PCT), the Loop of Henle (LOH), and the distal convoluted tubule (DCT).
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
1.3K

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Related Experiment Video

Updated: Aug 23, 2025

A Simplified Method for Generating Kidney Organoids from Human Pluripotent Stem Cells
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A Simplified Method for Generating Kidney Organoids from Human Pluripotent Stem Cells

Published on: April 13, 2021

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Functional renal collecting ducts from human PSCs.

Shunsuke Tanigawa1, Ryuichi Nishinakamura1

  • 1Department of Kidney Development, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860-0811, Japan.

Cell Stem Cell
|November 4, 2022
PubMed
Summary

Researchers developed a new method to create kidney collecting duct cells from human stem cells. This breakthrough aids in understanding kidney function and homeostasis.

Area of Science:

  • Nephrology
  • Stem Cell Biology
  • Biotechnology

Background:

  • Collecting ducts are crucial for kidney function, regulating water, electrolyte balance, and urine pH.
  • Maintaining body homeostasis relies on the proper functioning of these kidney structures.

Purpose of the Study:

  • To establish a protocol for generating functional kidney collecting duct cells.
  • To utilize human pluripotent stem cells for creating these specialized kidney cells.

Main Methods:

  • Employing a novel protocol developed by Shi et al. in Nature Biotechnology.
  • Differentiating human pluripotent stem cells into collecting duct cell lineages.

Main Results:

  • Successful generation of functional collecting duct cells from human pluripotent stem cells.

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Guided Differentiation of Mature Kidney Podocytes from Human Induced Pluripotent Stem Cells Under Chemically Defined Conditions
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Related Experiment Videos

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  • The generated cells exhibit characteristics of native kidney collecting ducts.

    • Conclusions:

    • The reported protocol offers a viable method for producing kidney collecting duct cells.
    • This advancement has implications for studying kidney diseases and developing regenerative therapies.