Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Neurogenesis and Regeneration of Nervous Tissue

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

Neural Regulation

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Workplace Lactation in Neurology: Barriers and Opportunities.

Neurology. Clinical practice·2026

Same author

Guidelines for Neuroprognostication in Critically ill Adults with Acute Ischemic Stroke.

Neurocritical care·2026

Same author

Ethical Challenges, Treatment Decisions, and Research Outcomes in Neurocritical Care.

Neurocritical care·2026

Same author

Guidelines for Neuroprognostication in Critically Ill Adults with Status Epilepticus.

Neurocritical care·2026

Same author

Documented Family-Clinician Interactions Prior to Palliative Care Consultation Associated With Less Withdrawal of Life-Sustaining Therapy Among Patients With Traumatic Brain Injury.

The American journal of hospice & palliative care·2025

Same author

Assessing functional communication in patients emerging from a disorder of consciousness: Impact of task and stimuli on response accuracy.

Clinical rehabilitation·2025

Search research articles

Related Experiment Video

Updated: Aug 23, 2025

A Neurite Outgrowth Assay and Neurotoxicity Assessment with Human Neural Progenitor Cell-Derived Neurons

A Neurite Outgrowth Assay and Neurotoxicity Assessment with Human Neural Progenitor Cell-Derived Neurons

Published on: August 6, 2020

Neuroprognostication.

Victoria Fleming¹, Susanne Muehlschlegel²

¹Department of Neurology, University of Massachusetts Chan Medical School, 55 Lake Avenue North, S-5, Worcester, MA 01655, USA.

Critical Care Clinics

|November 4, 2022

Summary

This summary is machine-generated.

Neuroprognostication for severe acute brain injury lacks guidelines, leading to variability. This review explores current literature, challenges, and proposes scientific, patient-centered approaches to improve clinical prognostication.

Keywords:

Neurocritical care Prognosis Prognostication Shared decision-making Surrogate decision-makers Uncertainty

More Related Videos

Determining the Functional Status of the Corticospinal Tract Within One Week of Stroke

Determining the Functional Status of the Corticospinal Tract Within One Week of Stroke

Published on: February 22, 2020

Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases

Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases

Published on: June 28, 2019

Related Experiment Videos

Last Updated: Aug 23, 2025

A Neurite Outgrowth Assay and Neurotoxicity Assessment with Human Neural Progenitor Cell-Derived Neurons

A Neurite Outgrowth Assay and Neurotoxicity Assessment with Human Neural Progenitor Cell-Derived Neurons

Published on: August 6, 2020

Determining the Functional Status of the Corticospinal Tract Within One Week of Stroke

Determining the Functional Status of the Corticospinal Tract Within One Week of Stroke

Published on: February 22, 2020

Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases

Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases

Published on: June 28, 2019

Area of Science:

Neurocritical care
Clinical neurology
Medical prognostication

Background:

Severe acute brain injury incapacitates patients, necessitating surrogate medical decision-making.
Clinicians rely on prognostication for critical decisions, but current neuroprognostication lacks standardized guidelines.
This variability makes neuroprognostication an "art" rather than a science.

Purpose of the Study:

To review the current literature on prognostication in neurocritical care.
To identify existing challenges in clinical neuroprognostication.
To propose future research directions for scientific and patient-centered prognostication.

Main Methods:

Systematic review of existing literature on neuroprognostication.
Analysis of current challenges and variability in clinical practice.
Synthesis of findings to suggest future research avenues.

Main Results:

Significant variability exists in current neuroprognostication practices.
Lack of standardized guidelines contributes to inconsistent clinical outcomes.
Current approaches are often perceived as subjective or artistic.

Conclusions:

Standardized guidelines are needed to reduce variability in neuroprognostication.
Future research should focus on developing scientific, evidence-based methods.
Patient-centered approaches are crucial for improving decision-making in neurocritical care.