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SCUBE1 is associated with thrombotic complications, disease severity, and in-hospital mortality in COVID-19 patients

Kenan Toprak1, Mustafa Kaplangoray2, Ali Palice2

  • 1Department of Cardiology, Faculty of Medicine, Harran University, Sanliurfa, Turkey.

Thrombosis Research
|November 5, 2022
PubMed

Insights

Signal peptide-CUB-EGF domain-containing protein 1 (SCUBE1) levels are elevated in COVID-19 patients and predict severe disease and mortality. Higher SCUBE1 indicates increased thrombotic risk, suggesting it as a therapeutic target.

Area of Science:

  • Biochemistry
  • Immunology
  • Pathology

Background:

  • COVID-19 is associated with significant thrombotic complications, mortality, and morbidity.
  • The role of Signal peptide-CUB-EGF domain-containing protein 1 (SCUBE1) in COVID-19-related thrombosis remains unclear.

Purpose of the Study:

  • To investigate the diagnostic and prognostic value of SCUBE1 levels in COVID-19 patients.
  • To clarify the relationship between SCUBE1 and thrombosis risk in COVID-19.

Main Methods:

  • Compared SCUBE1 levels in 553 COVID-19 patients versus 553 healthy controls.
  • Analyzed SCUBE1 levels in relation to disease severity, thrombotic complications, and in-hospital mortality.

Main Results:

  • SCUBE1 levels were significantly higher in COVID-19 patients than controls (p < 0.001).
  • Elevated SCUBE1 correlated with severe disease and thrombotic complications (p < 0.001).
  • SCUBE1 independently predicted in-hospital mortality (p < 0.001).

Conclusions:

  • SCUBE1 is a potential determinant of thrombotic complications in COVID-19.
  • Inhibiting SCUBE1 may represent a therapeutic strategy for COVID-19 patients.
Abstract

Keywords:
COVID-19In-hospital mortalitySCUBE1Thrombotic complications

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