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Related Experiment Video

Updated: Aug 23, 2025

Melt Electrospinning Writing of Three-dimensional Poly(ε-caprolactone) Scaffolds with Controllable Morphologies for Tissue Engineering Applications
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Structurally stable and surface-textured polylactic acid/copolymer/poly (ε-caprolactone) blend-based electrospun

Deepika Sharma1, Ahana Banerjee2, Jayanta Bhattacharyya2

  • 1Department of Materials Science and Engineering Indian Institute of Technology Delhi, Hauz Khas, New Delhi 110016, India.

Colloids and Surfaces. B, Biointerfaces
|November 6, 2022
PubMed
Summary

Interface-engineered electrospun mats (EMs) using copolymer (COP) enhanced PLA/PCL blends promote bone healing. These functionalized EMs facilitate cell attachment and biomineralization for improved tissue regeneration.

Keywords:
Aliphatic polyestersConstructsCopolymerElectrospinningPhysicomechanical properties

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Polymer Chemistry

Background:

  • Developing advanced biomaterials is crucial for effective tissue regeneration, particularly for bone, cartilage, and dental applications.
  • Existing materials often face challenges with biocompatibility, mechanical properties, and promoting cellular integration.
  • Interface engineering of polymer blends offers a promising strategy to overcome these limitations.

Purpose of the Study:

  • To develop nanotextured, copolymer (COP)-mediated electrospun mats (EMs) from PLA/PCL blends for enhanced biomimetic properties.
  • To investigate the impact of COP incorporation on the thermal, mechanical, and surface characteristics of the EMs.
  • To evaluate the potential of these engineered EMs in promoting cell attachment and biomineralization for guided tissue healing.

Main Methods:

  • Fabrication of PLA/PCL (70:30 w/w) blend-based EMs with nanotexturing and COP mediation.
  • Characterization of thermal stability, crystallinity, tensile properties, and dynamic relaxation response.
  • Surface analysis including zeta potential measurement and nano-hydroxyapatite (n-HA) ion attachment.
  • In vitro assessment of L929 fibroblast cell attachment and viability.

Main Results:

  • COP incorporation enhanced pliability by reducing crystallinity (12-23%) while maintaining thermal stability (300-350°C).
  • Tensile strength increased by ~75% with COP, and dynamic relaxation shifted to lower temperatures.
  • Zeta potential was tunable with COP content, facilitating controlled Ca2+ ion and n-HA attachment (~13% for ~5 phr COP).
  • EMs with ≤5 phr COP showed uniform n-HA dispersion and promoted selective fibroblast attachment (~200% viability for ~2.5 phr COP).

Conclusions:

  • Interface-engineered PLA/PCL EMs with COP show tunable surface properties and improved mechanical pliability.
  • These functionalized EMs effectively support n-HA integration and enhance L929 fibroblast cell attachment.
  • The developed constructs hold significant potential for augmenting biomineralization and accelerating healing in bone, cartilage, and dental applications.