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Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
Published on: April 20, 2018
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Distinct Failure Patterns in Hypopharyngeal Cancer Patients Receiving Surgery-Based Versus Radiation-Based Treatment
Yu-Hsuan Lin1,2, Jenn-Ren Hsiao3,4, Yuan-Hua Wu5,6
1Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, 70456, Taiwan.
Annals of Surgical Oncology
|November 6, 2022
Summary
Primary operation with adjuvant therapy (OP-CRT) offers better local control for advanced hypopharyngeal cancer than definitive chemoradiation (CCRT). However, OP-CRT increases the risk of distant metastases, though overall survival remains similar between the two treatment strategies.
Area of Science:
- Oncology
- Head and Neck Cancer Research
- Treatment Strategy Comparison
Background:
- Advanced hypopharyngeal squamous cell carcinoma (HPSCC) treatment typically involves primary operation followed by adjuvant (chemo-)radiotherapy (OP-CRT) or definitive chemoradiation (CCRT).
- Understanding failure patterns and long-term outcomes is crucial for optimizing treatment for this aggressive cancer.
- This study retrospectively reviewed patients with pathologically confirmed HPSCC treated between 2007 and 2015.
Purpose of the Study:
- To compare the failure patterns between OP-CRT and CCRT in patients with advanced HPSCC.
- To evaluate and contrast long-term survival outcomes associated with these two primary treatment strategies.
- To analyze failure patterns based on the 7th American Joint Committee on Cancer staging system.
Main Methods:
- Retrospective review of 198 pathologically confirmed advanced HPSCC patients.
- Patients received either primary operation with adjuvant (chemo-)radiotherapy (OP-CRT) or definitive chemoradiation (CCRT).
- Failure patterns and survival outcomes were compared, stratified by AJCC staging and treatment modality.
Main Results:
- OP-CRT demonstrated superior 3-year local relapse-free survival for T3 and T4a stages and regional relapse-free survival for N2b+2c compared to CCRT.
- For stage IVA HPSCC, OP-CRT showed better 3-year loco-regional relapse-free survival but a trend towards poorer distant metastasis-free survival.
- Both treatment strategies yielded comparable 3-year and 5-year overall survival (OS) rates.
Conclusions:
- While OP-CRT and CCRT offer similar overall survival for advanced HPSCC, their failure patterns differ significantly.
- OP-CRT excels in loco-regional control but is associated with a higher likelihood of distant metastases.
- Detailed analysis of failure patterns is essential for developing improved therapeutic strategies for HPSCC.
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