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FPIES: Data for Germany in international comparison.

Sunhild Gernert1, Antje Finger1,2, Lars Lange1

  • 1GFO Kliniken Bonn, St. Marien-Hospital, Department of Pediatrics, Bonn, and.

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|November 7, 2022
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Summary

Food protein-induced enterocolitis syndrome (FPIES) is a rare food allergy. In Germany, common triggers include cow's milk, fish, vegetables, and meat, differing from international patterns.

Keywords:
FPIESGermanycomplementary feedingnon-IgE-mediated food allergytolerancetriggering foods

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Area of Science:

  • Allergy and Immunology
  • Pediatric Gastroenterology

Background:

  • Food protein-induced enterocolitis syndrome (FPIES) is a rare, non-IgE-mediated food allergy.
  • Triggering foods for FPIES differ from typical IgE-mediated food allergies.
  • Limited data existed on FPIES triggers specifically within Germany.

Purpose of the Study:

  • To establish an advisory basis for managing German FPIES patients.
  • To identify the most common FPIES triggers in Germany.
  • To compare German FPIES trigger data with international findings.

Main Methods:

  • A large, multicenter study was conducted.
  • Data on FPIES triggers in German patients were collected and analyzed.
  • International FPIES trigger data were used for comparison.

Main Results:

  • Cow's milk, fish, vegetables, and meat were identified as the most frequent FPIES triggers in Germany.
  • A significant majority of children (84%) reacted to a single food trigger.
  • Clear differences were observed when comparing German data to international FPIES trigger patterns.

Conclusions:

  • Regional data are crucial for effective FPIES patient counseling.
  • The identified common triggers in Germany provide a basis for specific recommendations.
  • The prognosis for FPIES is generally good and depends on the specific trigger food.