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The first described case of Lodderomyces elongisporus meningitis

Taylor Dear1,2, Yeyao Joe Yu2,3, Sachin Pandey2,4

  • 1Department of Medicine, Western University, London, Ontario, Canada.

Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal Officiel De L'Association Pour La Microbiologie Medicale Et L'Infectiologie Canada
|November 7, 2022
PubMed

Insights

This report details the first meningitis case caused by Lodderomyces elongisporus, identified via fungal sequencing. Treatment with fluconazole and CSF diversion improved patient outcomes.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Neuroscience

Background:

  • Lodderomyces elongisporus is a rare fungal pathogen.
  • Fungal meningitis is a serious central nervous system infection.
  • Accurate identification of fungal species is crucial for effective treatment.

Observation:

  • A patient presented with meningitis, initially with negative fungal cultures.
  • Diagnosis of Lodderomyces elongisporus meningitis was confirmed through fungal internal transcribed spacer sequencing of an arachnoid biopsy.
  • The patient had previously been treated for presumed Candida parapsilosis infection.

Findings:

  • This is the first documented case of meningitis caused by Lodderomyces elongisporus.
  • Fungal sequencing proved essential for diagnosis when cultures were negative.
  • Treatment with fluconazole and cerebrospinal fluid diversion (lumbar drain and ventriculopleural shunt) led to clinical improvement.

Implications:

  • Highlights the potential for Lodderomyces elongisporus to cause invasive CNS infections.
  • Emphasizes the utility of molecular methods for diagnosing fungal meningitis.
  • Provides insights into managing fungal meningitis-associated hydrocephalus and treatment strategies.
Keywords:
ITS sequencingLodderomyces elongisporusfungal meningitis

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