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Updated: Aug 22, 2025

Assessment of Myofilament Ca2+ Sensitivity Underlying Cardiac Excitation-contraction Coupling
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Distinct Mechanisms for Increased Cardiac Contraction Through Selective Alteration of Either Myosin or Troponin

Rohit R Singh1,2, Rebecca E Slater1, Jinghong Wang1

  • 1Amgen Research, Department of Cardiometabolic Disorders, Amgen, South San Francisco, California, USA.

JACC. Basic to Translational Science
|November 7, 2022
PubMed

Keywords:
AAA, transgenic mice expressing alanine at Serine 273, 282, and 302DDD, transgenic mice expressing aspartate at Serine 273, 282, and 302Fmax, maximal force per cross-sectional areaHF, heart failureKO, knock-outLV, left ventricleM, myosin-selective small moleculeMYBPC3OM, omecamtiv mecarbilSRX, super relaxed stateT, troponin-selective small moleculecMyBP-C phosphorylationcMyBP-C, cardiac myosin binding protein-Cheart failurektr, rate of force redevelopmentmyosinpCa50, half maximal effective calcium concentrationtWt, transgenic wild typetroponin

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