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Published on: May 19, 2020
Interstitial Collagen Loss, Myocardial Remodeling, and Function in Primary Mitral Regurgitation
Mustafa I Ahmed1, Efstathia Andrikopoulou1, Jingyi Zheng2
1Division of Cardiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Abstract:
Interstitial collagen loss and cardiomyocyte ultrastructural damage accounts for left ventricular (LV) sphericity and decrease in LV twist and circumferential strain. Normal LV diastolic function belies significantly abnormal left atrial (LA) function and early LV diastolic untwist rate. This underscores the complex interplay of LV and LA myocardial remodeling and function in the pathophysiology of primary mitral regurgitation. In this study, we connect LA function with LV systolic and diastolic myocardial remodeling and function using cardiac magnetic resonance tissue tagging in primary mitral regurgitation.
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