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Updated: Aug 22, 2025
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An Ultrahigh-throughput Microfluidic Platform for Single-cell Genome Sequencing
Published on: May 23, 2018
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Single-cell sequencing technologies in bladder cancer research: Applications and challenges
Tianqi Lyu1, Yuanbin Lin1, Kerong Wu2
1Cixi Institute of Biomedical Engineering, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Science (CAS), Ningbo, China.
Frontiers in Genetics
|November 7, 2022
Summary
Single-cell sequencing reveals bladder cancer
Area of Science:
- Oncology
- Genomics
- Molecular Biology
Background:
- Bladder cancer is a common malignancy with significant molecular heterogeneity.
- Current treatments often yield unsatisfactory outcomes due to a lack of specific biomarkers.
- Intra-tumoral heterogeneity poses challenges for targeted therapy and immunotherapy.
Purpose of the Study:
- To review the application of single-cell sequencing in bladder cancer research.
- To elucidate intra-tumoral heterogeneity and tumor microenvironment complexity.
- To identify novel therapeutic targets and prognostic models for precision medicine.
Main Methods:
- Review of studies utilizing single-cell sequencing technologies in bladder cancer.
- Analysis of data on tumor cell heterogeneity and microenvironment.
- Examination of findings related to therapeutic resistance and biomarker discovery.
Main Results:
- Single-cell techniques provide deep insights into bladder tumor cell heterogeneity.
- The tumor microenvironment's complexity is better understood through single-cell analysis.
- Mechanisms of therapeutic resistance and detection of exfoliated tumor cells are facilitated.
- Key therapeutic targets and prognostic models have been identified.
Conclusions:
- Single-cell sequencing is a powerful tool for advancing bladder cancer research.
- It offers new perspectives on tumor biology, heterogeneity, and the microenvironment.
- This technology holds promise for developing precision medicine approaches in bladder cancer treatment.
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