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Updated: Aug 22, 2025

Non-invasive Optical Imaging of the Lymphatic Vasculature of a Mouse
Published on: March 8, 2013
Alternative Evaluation of the Right Axillary Lymphatic Pathway by Using Dynamic Contrast-enhanced MR Lymphangiography
Michael Simon1, Yoav Dori1, Christopher L Smith1
1Department of Radiology, Cooperman Barnabas Medical Center, Livingston, NJ (M.S.); Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa (Y.D., C.L.S., D.M.B., G.K., J.B.R.); and Department of Cardiology (Y.D., C.L.S.), Department of Radiology (D.M.B., G.K., J.B.R.), Department of Pathology and Laboratory Medicine (L.F.S.), and Complex Vascular Anomalies Frontier Program (D.M.A.), Children's Hospital of Philadelphia, 3401 Civic Center Blvd, 3NW40, Philadelphia, PA 19104.
Abstract:
The lymphatic system plays an integral part in fluid homeostasis. Disturbances in lymphatic pathways are congenital, posttraumatic, or posttreatment related, such as after Fontan palliation. Lymphatic pathway evaluation is challenging because of the difficulty in introducing contrast material into the lymphatics. Intranodal, intramesenteric, and intrahepatic dynamic contrast-enhanced MR lymphangiography (DCMRL) offer better visualization of major lymphatic pathways. However, these techniques exclude pathways outside the central conduction system, preventing the visualization of abnormalities and, thus, administration of treatment. The authors describe alternative imaging of an axillary pathway via DCMRL in a patient with a symptomatic chylous effusion not previously assessed with current techniques. Keywords: Lymphatic, MR-Dynamic Contrast Enhanced, Pediatrics, Thorax, Pleura Supplemental material is available for this article. © RSNA, 2022.
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