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Use of Fresh-frozen Plasma in Newborn Infants
Manvi Tyagi1, Akhil Maheshwari2, Brunetta Guaragni3
1Department of Pediatrics, Augusta University, Georgia, United States of America.
Insights
Fresh-frozen plasma (FFP) transfusions are given to nearly 10% of critically ill infants to prevent bleeding. This review examines FFP use in neonatology, aiming to establish best practices for infant safety.
Area of Science:
- Neonatal Medicine
- Pediatric Hematology
- Transfusion Medicine
Background:
- Nearly 10% of premature and critically ill infants receive fresh-frozen plasma (FFP) transfusions.
- There is limited data on predictors of bleeding and FFP efficacy in neonates.
- Optimal FFP use in non-bleeding infants with abnormal coagulation remains controversial.
Purpose of the Study:
- To review current evidence on FFP use in neonatology.
- To propose evidence-based recommendations for safe FFP administration in neonates.
Main Methods:
- Systematic review of clinical studies on FFP in neonatology.
- Analysis of data to identify predictors of bleeding and FFP efficacy.
- Synthesis of evidence to formulate best practice guidelines.
Main Results:
- Limited data currently exists regarding predictors of bleeding and FFP efficacy in neonates.
- Evidence on optimal FFP use in non-bleeding neonates with abnormal coagulation is lacking.
- The review synthesizes available data to inform clinical decision-making.
Conclusions:
- Further research is needed to clarify FFP efficacy and identify optimal use in neonates.
- Best practice recommendations are proposed to enhance the safety of FFP transfusions in infants.
- Establishing consensus on FFP administration is crucial for improving outcomes in high-risk neonates.
Abstract:
Nearly 10% of premature and critically ill infants receive fresh-frozen plasma (FFP) transfusions to reduce their high risk of bleeding. The authors have only limited data to identify relevant clinical predictors of bleeding and to evaluate the efficacy of FFP administration. There is still no consensus on the optimal use of FFP in infants who have abnormal coagulation parameters but are not having active bleeding. The aims of this review are to present current evidence derived from clinical studies focused on the use of FFP in neonatology and then use these data to propose best practice recommendations for the safety of neonates receiving FFP.
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