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Mitogen-activated protein kinase kinase 7 in inflammatory, cancer, and neurological diseases

Amada D Caliz1, Anastassiia Vertii2, Vijay Fisch1

  • 1Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.

Frontiers in Cell and Developmental Biology
|November 7, 2022
PubMed

Insights

Mitogen-activated protein kinase kinase 7 (MKK7) regulates key cell processes. New research reveals MKK7’s crucial JNK-independent functions in inflammation, cancer, and neurological diseases.

Area of Science:

  • Molecular Biology
  • Cell Signaling
  • Physiology

Background:

  • Mitogen-activated protein kinase kinase 7 (MKK7) is a dual-specificity kinase involved in stress responses.
  • MKK7 and MKK4 pathways mediate c-Jun N-terminal kinase (JNK) signaling.
  • Limited research has focused on MKK7's independent functions.

Purpose of the Study:

  • To review the JNK-dependent and JNK-independent functions of MKK7.
  • To highlight MKK7's role in various physiological processes and diseases.

Main Methods:

  • Review of existing literature.
  • Analysis of findings from in vivo genetically deficient models.

Main Results:

  • MKK7 controls proliferation and differentiation.
  • MKK7 has documented JNK-independent functions.
  • MKK7 plays a role in inflammation, cytokine production, cancer, and neurological diseases.

Conclusions:

  • MKK7 exhibits significant JNK-dependent and JNK-independent roles.
  • Further investigation into MKK7's functions is warranted for understanding disease mechanisms.
Keywords:
MAPKscancerinflammationneuronsenescencesignalingstress

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