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Vaccinations

Vaccinations

Immunological Memory

Immunological Memory

Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...

Factors Affecting the Risk of Infection

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...

Dosage Regimen: Fixed Dose

Dosage Regimen: Fixed Dose

Fixed-dose regimens are a common approach to administer drugs to achieve and maintain desired levels of the drug in the body. In this dosing strategy, a specific amount of medication is given at regular intervals, often multiple times a day, to ensure a consistent drug concentration in the bloodstream.
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...

Desensitization and Tachyphylaxis

Desensitization and Tachyphylaxis

Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.

Cross-reactivity

Cross-reactivity

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Updated: Aug 22, 2025

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19

Published on: February 16, 2022

COVID-19 vaccination: Why extend the interval between doses?

Caroline Quach^1,2,3, Shelley Deeks^3,4,5

¹Department of Microbiology, Infectious Diseases & Immunology, University of Montreal, Montreal, Quebec, Canada.

Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal Officiel De L'Association Pour La Microbiologie Medicale Et L'Infectiologie Canada

|November 7, 2022

Summary

To speed up COVID-19 protection in Canada, the National Advisory Committee on Immunization (NACI) recommended extending the interval between vaccine doses. This strategy aimed to maximize initial vaccinations amid supply shortages.

Keywords:

COVID-19 interval public health vaccination

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Area of Science:

Immunology
Public Health Policy
Vaccinology

Background:

Ongoing COVID-19 morbidity and mortality in Canada.
Limited availability of authorized COVID-19 vaccines.
Urgent need for rapid population protection.

Purpose of the Study:

Explain the rationale behind NACI's extended COVID-19 vaccine dosing interval recommendation.
Provide healthcare providers with information to support patient vaccination.
Address questions and concerns regarding the dosing strategy.

Main Methods:

Review of scientific evidence.
Application of immunological principles.
Consideration of historical vaccine data.
Analysis of epidemiological modeling studies.
Evaluation of ethical, equity, feasibility, and acceptability factors.

Main Results:

NACI issued a strong recommendation for an extended interval between COVID-19 vaccine doses.
The recommendation was based on a comprehensive review and multi-factorial analysis.
The strategy aimed to accelerate widespread vaccine coverage.

Conclusions:

The extended dosing interval is a strategic public health measure to maximize immediate population protection.
Further information is provided to support healthcare providers in the vaccination rollout.
The decision balances vaccine efficacy with the urgent need for broad immunization.