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Accessory Structures of the Skin: Nails01:05

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The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
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Distinctive nail pattern following androgen replacement therapy.

Ippei Miyata1, Atsushi Nagai2

  • 1Department of Pediatrics Kawasaki Medical School Okayama Japan.

IJU Case Reports
|November 7, 2022
PubMed
Summary

Androgen replacement therapy can cause a unique "washboard-like" nail pattern. Increased therapy frequency correlated with wider nail ridges, suggesting a direct link between androgens and nail growth changes.

Keywords:
androgenhormone replacement therapylate onset hypogonadism syndromenails

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Area of Science:

  • Endocrinology
  • Dermatology

Background:

  • Androgen replacement therapy (ART) is used for treating conditions like late-onset hypogonadism.
  • Nail changes are not commonly reported side effects of ART.

Observation:

  • A 47-year-old male patient on ART developed a distinct "washboard-like" pattern on his fingernails.
  • The patient noted accelerated nail growth after his ART regimen was intensified.

Findings:

  • The observed nail pattern, characterized by widening ridges, is hypothesized to be a direct result of ART.
  • Changes in nail morphology appeared to correlate with the strengthening of the androgen therapy.

Implications:

  • This case highlights a potential, previously uncharacterized dermatological side effect of androgen therapy.
  • Clinicians should be aware of possible nail abnormalities in patients undergoing androgen replacement.
  • Further research may elucidate the mechanism linking androgens to nail growth and structure.