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Prenatal titanium exposure and child neurodevelopment at 1 year of age: A longitudinal prospective birth cohort study

Yangqian Jiang1, Yongyue Wei2, Wenhui Guo1

  • 1State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, 211166, Jiangsu, China; Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, Jiangsu, China.

Chemosphere
|November 7, 2022
PubMed

Insights

Prenatal titanium exposure may harm child language development. Higher exposure in early pregnancy was linked to lower language scores and increased risk of delay in toddlers, suggesting titanium

Area of Science:

  • Environmental Health
  • Neurodevelopmental Toxicology
  • Pediatric Health

Background:

  • Animal studies suggest prenatal titanium exposure can cause neurotoxicity.
  • Human data on prenatal titanium exposure and child neurodevelopment is limited.
  • Titanium's potential impact on developing brains requires investigation.

Purpose of the Study:

  • To investigate the association between prenatal titanium exposure and neurodevelopment in children.
  • To quantify the relationship between maternal urinary titanium levels and child developmental outcomes.
  • To identify potential risks of titanium exposure during early pregnancy.

Main Methods:

  • Prospective cohort study recruiting pregnant women (2014-2017).
  • Measurement of urinary titanium concentrations in the first trimester.
  • Assessment of child neurodevelopment using the Gesell Developmental Schedules at one year.
  • Statistical analysis using multivariable linear and robust modified Poisson regressions.

Main Results:

  • Higher prenatal titanium exposure was associated with lower developmental quotient scores in the language domain.
  • Children in the highest tertile of exposure had significantly lower language scores compared to the lowest tertile.
  • Increased risk of language development delay was observed in children with higher prenatal titanium exposure.
  • No significant associations were found for motor, adaptive, or social development.

Conclusions:

  • Prenatal higher titanium exposure is linked to impaired language development in children.
  • Titanium may act as a developmental neurotoxicant, particularly affecting language acquisition.
  • Further research is warranted to understand the mechanisms and long-term effects of prenatal titanium exposure.

Keywords:
Child neurodevelopmentPrenatal exposureTitanium

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