FDG PET/CT Aiding in Early Diagnosis of Central Pontine Myelinolysis

Area of Science:

• Neurology
• Nuclear Medicine
• Radiology

Background:

• Central pontine myelinolysis (CPM) is a rare neurological condition.
• Diagnosis can be challenging with conventional imaging.
• Electrolyte imbalances like hyponatremia are often associated with CPM.

Observation:

• A 70-year-old male presented with altered sensorium and tremors.
• Initial laboratory tests showed hyponatremia and hypokalemia.
• Magnetic Resonance Imaging (MRI) of the brain was unremarkable.

Findings:

• Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (FDG PET/CT) was performed to investigate potential malignancy or paraneoplastic syndrome.
• FDG PET/CT revealed focal radiotracer uptake in the pons.
• This uptake pattern was consistent with central pontine myelinolysis, despite the absence of CT abnormalities.

Implications:

• FDG PET/CT can be a valuable tool for the early diagnosis of CPM.
• This technique offers diagnostic utility when conventional imaging modalities like MRI are inconclusive.
• Early diagnosis facilitates timely management and can improve patient outcomes.