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Updated: Aug 22, 2025
Physiology Lab Demonstration: Glomerular Filtration Rate in a Rat
Published on: July 26, 2015
Effect of glomerular filtration rate in patients undergoing percutaneous coronary intervention: A systematic review
Xiang Zhu1, Pin Zhang, Jinrui Xiong
1Jiangxi Provincial Key Laboratory of Preventive Medicine, School of Public Health, Nanchang University, Nanchang, People's Republic of China.
Background:
Through meta-analysis of the relationship between glomerular filtration rate and major adverse cardiovascular events (MACE) after percutaneous coronary intervention (PCI), we studied the impact of glomerular filtration rate on the prognosis of PCI.
Methods:
We collected literature on the incidence of MACE in patients with chronic kidney disease (CKD; estimated glomerular filtration rate < 60 mL/minute/1.73 m2) and patients with nonchronic kidney disease undergoing PCI. The search period was from January 1, 2000, to November 1, 2021. The searched databases included CNKI, Chinese Wanfang Data, China Biology Medicine disc, Web of Science, PubMed, and Cochrane Library. We used subgroup analysis and meta-regression to assess heterogeneity.
Results:
Twenty-one eligible studies were included, with 46,255 samples included, 4903 cases of MACE (10.6%), and patients with CKD had a higher risk of MACE after PCI (Risk ratios = 1.67; 95% confidence interval: 1.51-1.85). Multivariate meta regression results show that heterogeneity is related to region. The risk of MACEs in patients with CKD is different in different regions, and North America has the lowest risk, with an risk ratios value of 1.21 (95% confidence interval: 1.08-1.35).
Conclusion:
Chronic kidney disease will increase the probability of MACE in patients with myocardial infarction after PCI and affect the prognosis of PCI. Therefore, clinical attention should be given to assessing glomerular filtration rate effects while treating patients with myocardial infarction with the PCI procedure.
Insights
Patients with chronic kidney disease (CKD) face a significantly higher risk of major adverse cardiovascular events (MACE) after percutaneous coronary intervention (PCI). Monitoring glomerular filtration rate is crucial for improving PCI outcomes in these individuals.
Area of Science:
- Cardiology
- Nephrology
- Public Health
Background:
- Assessing the impact of glomerular filtration rate (GFR) on major adverse cardiovascular events (MACE) following percutaneous coronary intervention (PCI) is critical for patient prognosis.
- Chronic kidney disease (CKD) is a significant comorbidity that may influence cardiovascular outcomes after PCI.
Approach:
- A comprehensive meta-analysis was conducted, synthesizing data from 21 studies encompassing 46,255 patients undergoing PCI.
- Literature searches were performed across major databases (PubMed, Web of Science, Cochrane Library, etc.) from January 2000 to November 2021.
- Subgroup analysis and meta-regression were employed to investigate heterogeneity and regional variations in MACE risk.
Key Points:
- Patients with CKD (eGFR < 60 mL/min/1.73 m²) exhibited a 1.67-fold increased risk of MACE post-PCI compared to non-CKD patients.
- Regional differences in MACE risk were observed, with North America showing the lowest risk (RR = 1.21).
- Heterogeneity in MACE risk among CKD patients was significantly associated with geographical region.
Conclusions:
- CKD substantially increases the likelihood of MACE in patients undergoing PCI for myocardial infarction, negatively impacting overall prognosis.
- Clinical management strategies for patients with myocardial infarction undergoing PCI should incorporate thorough assessment of GFR and CKD status.
- Proactive monitoring and management of kidney function are essential for optimizing PCI outcomes and reducing cardiovascular event rates.
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