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In situ visualization of aortic dissection propagation in notched rabbit aorta using synchrotron X-ray tomography
J Brunet1, B Pierrat2, J Adrien3
1Mines Saint-Étienne, Univ Jean Monnet, INSERM, U 1059 Sainbiose, 42023, Saint-Étienne, France; European Synchrotron Radiation Facility (ESRF), Grenoble, France; Department of Mechanical Engineering, University College London, London, UK.
Acta Biomaterialia
|November 7, 2022
Summary
This study used in vitro aortic dissection models and advanced imaging to visualize dissection propagation. Findings reveal notch geometry correlates with critical pressure, aiding risk assessment for patients.
Area of Science:
- Biomedical Engineering
- Cardiovascular Research
- Medical Imaging
Background:
- Aortic dissection is a complex cardiovascular condition that is challenging to study due to its dynamic nature.
- Understanding the mechanisms and factors contributing to aortic dissection propagation is crucial for patient risk stratification.
Purpose of the Study:
- To investigate the factors leading to aortic dissection propagation.
- To develop a method for in situ visualization and quantification of aortic dissection.
- To correlate aortic and intimal tear morphology with critical pressure.
Main Methods:
- Controlled in vitro aortic dissection using tension-inflation tests on notched rabbit aortic segments.
- In situ imaging combining conventional computed tomography (cCT) and synchrotron computed tomography (sCT).
- Quantification of macro- and micro-structural morphological changes during dissection.
Main Results:
- Demonstrated in situ quantification of aortic dissection morphology at various stages.
- Identified a correlation between notch geometry and critical pressure.
- Visualized phenomena preceding tear propagation, including bulge formation at the notch tip.
- Achieved the first real-time visualization of aortic dissection propagation with unprecedented resolution.
Conclusions:
- The developed method allows for unprecedented real-time visualization and quantification of aortic dissection.
- Notch morphology is a quantifiable predictor of critical pressure in aortic dissection.
- These findings are vital for developing improved criteria for identifying patients at risk of aortic dissection.
