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Chronic Obstructive Pulmonary Disease

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Author Spotlight: Evaluating the Therapeutic Efficacy of Moving Cupping Along Meridians for Acute Exacerbation of COPD

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[Chronic Cough in CANVAS].

Hiroshi Doi¹, Fumiaki Tanaka

¹Department of Neurology and Stroke Medicine, Yokohama City University Graduate School of Medicine.

Brain and Nerve = Shinkei Kenkyu No Shinpo

|November 7, 2022

Summary

This summary is machine-generated.

Chronic cough is a key symptom in RFC1 spectrum disorders, affecting at least 60% of patients with cerebellar ataxia with neuropathy and vestibular areflexia syndrome (CANVAS). This cough can precede neurological symptoms by decades, highlighting its diagnostic importance.

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Methods for Detecting Cough and Airway Inflammation in Mice

Methods for Detecting Cough and Airway Inflammation in Mice

Published on: August 2, 2024

Area of Science:

Neurology
Genetics
Pulmonology

Context:

RFC1 spectrum disorders present with diverse phenotypes, including cerebellar ataxia with neuropathy and vestibular areflexia syndrome (CANVAS).
Chronic cough is a prominent and often early symptom in these disorders.

Purpose:

To highlight chronic cough as a significant diagnostic feature of RFC1 spectrum disorders.
To discuss the potential role of the vagus nerve and cerebellum in cough generation within this patient group.

Summary:

At least 60% of patients with RFC1 spectrum disorders, specifically CANVAS, experience chronic, paroxysmal, spasmodic dry cough.
This cough frequently serves as the initial presenting symptom, sometimes appearing over 30 years before other neurological signs like ataxia.
The exact cause of the cough is unknown but may involve dysfunction of the vagus nerve's afferent pathway or cerebellar involvement.

Impact:

Elevates the recognition of chronic cough as a critical early indicator for RFC1-related conditions.
Suggests potential diagnostic and research avenues focusing on the neurological underpinnings of cough in these disorders.