Related Experiment Video
Updated: Aug 22, 2025

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
Published on: January 17, 2020
Regulation of Chirality in Metal-Organic Frameworks (MOFs) Based on Achiral Precursors through Substituent
Xiang-Jing Gao1,2, Ting-Ting Wu1, Fa-Yuan Ge1
1State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing 210023, People's Republic of China.
Abstract:
The generation and regulation of chirality are closely related to the origin of life. Using achiral precursors to spontaneously build chiral MOFs remains a major challenge. Here, a method to synthesize chiral MOFs from achiral precursors by utilizing chiral fragments was achieved. The transformation from chiral fragments of 1 to chiral frameworks of 2 and 3 was realized by modifying the substituents, and the enantiomer resolution of 3-P41212 and 3-P43212 was achieved by d/l camphoric acid. 3 was then further studied in applications.
More Related Videos
Related Concept Videos
Prochirality
Molecules with Multiple Chiral Centers
Chirality at Nitrogen, Phosphorus, and Sulfur
A consequence of chirality is the need for enantiomeric resolution. While this is theoretically possible for all...
Chirality
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...
Reduction of Alkenes: Asymmetric Catalytic Hydrogenation
The metal catalyst used can be either heterogeneous or homogeneous. When hydrogenation of an alkene generates a chiral center, a pair of enantiomeric products is expected to form. However, an enantiomeric excess of one of the products can be facilitated using an enantioselective reaction or an...
Naming Enantiomers

