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Intrathecal Application of a Fluorescent Dye for the Identification of Cerebrospinal Fluid Leaks in Cochlear Malformation
Published on: February 29, 2020
[Diagnostic value of computed tomographic cisternography and magnetic resonance hydrography in cerebrospinal fluid
Xing Lu1, Xiang Zhai1, Haiyan Li1
1Department of Otolaryngology Head and Neck Surgery,Tianjin Huanhu Hospital,Tianjin,300350,China.
Abstract:
Objective:To evaluate the accuracy of preoperative computed tomographic cisternography(CTC) and magnetic resonance hydrography(MRH)in the diagnosis of cerebrospinal fluid(CSF) rhinorrhea. Methods:Retrospective analysis was made on the data of 38 patients diagnosed as cerebrospinal rhinorrhea who completed preoperative HRCT, CTC and MRH examinations in the Department of Otolaryngology Head and Neck Surgery of Tianjin Huanhu Hospital from October 2016 to January 2022. The diagnostic accuracy of preoperative imaging examinations was compared according to the leak location found during operation. Results:Among all the 38 cases with CSF rhinorrhea, the detection rates of HRCT, CTC, and cranial MRH were 31.58%, 89.47%, and 60.53%, respectively. The accuracy of CTC was significantlyhigher than that of MRH ( χ²=8.49, P=0.007), and the accuracy of MRH was significantly higher than that of HRCT (χ²=6.41, P=0.01). Subgroup analyses were performed according to the precise positioning of cerebrospinal fluid rhinorrhea leakage. In patients with cerebrospinal fluid rhinorrhea located in ethmoid sinus, the accuracy of CTC(80.95% vs. 14.29%,P<0.01)and MRH(52.38% vs. 14.29%,P=0.02)were significantly higher than that of HRCT, but the accuracy but the difference between CTC and MRH between CTC and MRH was not statistically significant (P=0.10). The accuracy of CTC was significantly higher than that of MRH (100.00% vs. 61.54%, P=0.04) and HRCT (100.00% vs. 53.85%, P<0.01) in patients with CSF rhinorrhea located in sphenoid sinus. However, there was no significant difference in the accuracy between MRH and HRCT ( P=1.00). However, There was no significant difference in the accuracy of CTC, MRH and HRCT in patients with cerebrospinal fluid rhinorrhea located in frontal sinus. The accuracy of CTC and MRH was 84.62% and 57.69% respectively in 26 patients who failed to detect a CSF rhinorrhea by HRCT, and the difference was not statistically significant(χ²=4.59, P=0.06). Conclusion:The comprehensive application of the multiple imaging methods has important guiding significance for the accurate treatment and prognosis evaluation. CTC and MRH could improve the accuracy of the localization diagnosis of cerebrospinal fluid rhinorrhea.
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