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Updated: Aug 22, 2025

Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography FDG-PET/CT
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Improving Detection of CAD and Prognosis with PET/CT Quantitative Absolute Myocardial Blood Flow Measurements

Vincent Ngo1, Patrick Martineau2,3, Francois Harel1

  • 1Department of Medical Imaging, Montreal Heart Institute, 5000 Belanger, Montreal, QC, H1C1C8, Canada.

Current Cardiology Reports
|November 8, 2022
PubMed
Abstract

Insights

Positron emission tomography myocardial perfusion imaging (PET MPI) with myocardial blood flow (MBF) quantification enhances coronary artery disease (CAD) detection and patient risk stratification. This method offers improved diagnostic accuracy and prognostic value for guiding clinical management.

Area of Science:

  • Cardiology
  • Nuclear Medicine
  • Medical Imaging

Background:

  • Positron emission tomography myocardial perfusion imaging (PET MPI) is a key tool for assessing coronary artery disease (CAD).
  • Accurate risk stratification is crucial for managing patients with suspected or established CAD.

Purpose of the Study:

  • To review the role of PET MPI in detecting CAD.
  • To highlight the diagnostic and prognostic benefits of myocardial blood flow (MBF) quantification in PET MPI.

Main Methods:

  • Review of current literature on PET MPI and MBF quantification in CAD.
  • Focus on the incremental value of MBF measurements over conventional perfusion imaging.

Main Results:

  • PET MPI with MBF quantification improves sensitivity and specificity for CAD detection.
  • Quantitative MBF measurements provide independent prognostic information.
  • MBF quantification aids in risk stratification and patient management.

Conclusions:

  • PET MPI incorporating MBF quantification is a powerful tool for CAD diagnosis and prognostication.
  • This approach enhances clinical decision-making for patients with CAD.
  • The review also addresses the application of PET MPI and flow quantification in cardiac allograft vasculopathy (CAV).
Keywords:
Coronary artery diseaseCoronary flow reserveMyocardial blood flowMyocardial flow reserveMyocardial perfusion imagingPositron emission tomography

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