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Updated: Aug 22, 2025
11:22
Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
Published on: October 15, 2019
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The relationship between menopausal syndrome and gut microbes
Yaqian Liu1, Ying Zhou2, Ting Mao3
1Gynecology, Guangzhou University of Traditional Chinese Medicine First Affiliated Hospital, Guangzhou, China.
BMC Women'S Health
|November 9, 2022
Summary
Menopausal syndrome (MPS) is linked to gut microbiota changes, with specific bacteria deficiencies correlating with sex hormone levels. These findings highlight gut dysbiosis as a factor in MPS, impacting women's health.
Area of Science:
- Microbiome research
- Women's health
- Menopause studies
Background:
- Gut microbiota composition varies between premenopausal and postmenopausal women.
- The relationship between gut dysbiosis and menopausal syndrome (MPS) remains largely unexplored.
- This study investigates the connection between MPS and gut microbial alterations.
Purpose of the Study:
- To explore the relationship between menopausal syndrome and gut microbiota.
- To identify specific gut microbes associated with MPS.
- To understand the functional implications of microbial changes in MPS.
Main Methods:
- Recruited 77 patients with MPS and 24 healthy menopausal women.
- Collected stool samples and clinical data, including hormone levels (FSH, LH, E2).
- Utilized 16S rRNA gene sequencing, LEfSe, Spearman correlation, and PICRUSt for analysis.
Main Results:
- LEfSe analysis revealed 14 species with significantly different abundances between groups.
- Estradiol (E2) positively correlated with Aggregatibacter segnis, Bifidobacterium animalis, and Acinetobacter guillouiae.
- Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) negatively correlated with these enriched species.
- PICRUSt identified enriched KEGG pathways related to cardiovascular disease and carbohydrate metabolism in MPS patients.
Conclusions:
- Gut microbiota dysbiosis is evident in menopausal syndrome (MPS).
- Specific bacterial deficiencies (A. segnis, B. animalis, A. guillouiae) are linked to sex hormone levels in MPS.
- MPS is characterized by altered microbial abundances and unique functional pathways.
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