Hypercarbia in a Pediatric Patient With Relapsed Medulloblastoma

Mitchell A Luangrath1, Mariko Sato2, Cody R Tigges1

  • 1Pediatric Critical Care Medicine, University of Iowa, Iowa City, USA.

Cureus
|November 9, 2022
PubMed

Insights

Recurrent medulloblastoma in children can manifest as respiratory failure due to brainstem involvement. This case highlights the need to consider central nervous system tumors in pediatric respiratory acidosis.

Area of Science:

  • Pediatric Oncology
  • Pediatric Neurology
  • Respiratory Medicine

Background:

  • Medulloblastoma is a common pediatric brain tumor.
  • Typical symptoms include increased intracranial pressure and ataxia.
  • Relapse is usually detected via surveillance imaging.

Related Concept Videos

Acute Respiratory Failure-III01:30

Acute Respiratory Failure-III

Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without...
271
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.9K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.4K