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Microneedle-based ocular drug delivery systems - recent advances and challenges
Piotr Gadziński1, Anna Froelich1, Monika Wojtyłko1
1Chair and Department of Pharmaceutical Technology, Poznan University of Medical Sciences.
Beilstein Journal of Nanotechnology
|November 9, 2022
Summary
Microneedle ocular patches offer a promising, non-invasive alternative to traditional eye drops for drug delivery. This review highlights advancements in microneedle technology for treating eye diseases.
Area of Science:
- Ophthalmology
- Biotechnology
- Materials Science
Background:
- Eye diseases and injuries are a global health concern.
- Current ocular drug delivery methods (eye drops, gels, ointments) face challenges with patient compliance and efficacy due to ocular barriers.
- Novel drug delivery systems are needed to overcome these limitations.
Purpose of the Study:
- To review recent advancements in microneedle-based ocular drug delivery systems.
- To summarize manufacturing technologies, classification, and ophthalmic applications of microneedles.
- To discuss the advantages, drawbacks, and challenges of microneedle patches for ocular drug delivery.
Main Methods:
- Review of scientific literature on microneedle technology for ophthalmic applications.
- Analysis of manufacturing techniques for microneedle ocular patches.
- Synthesis of research findings on the efficacy and safety of microneedle-based ocular drug delivery.
Main Results:
- Microneedle technology has significantly advanced, offering a non-invasive alternative for ocular drug administration.
- Various manufacturing technologies and classifications of microneedles have been developed for ophthalmic use.
- Studies demonstrate the potential of microneedle patches to improve drug delivery to the eye.
Conclusions:
- Microneedle ocular patches represent a significant development in drug delivery systems for eye diseases.
- Further research is needed to address challenges related to the unique ocular anatomy and physiology.
- Microneedle technology holds promise for improved patient compliance and therapeutic outcomes in ophthalmology.
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