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COVID-19 Positive Status is Associated with Increased In-hospital Mortality in Patients with Acute Myocardial
Nischit Baral1, Waiel Abusnina2, Shravya Balmuri1
1Department of Medicine, McLaren Flint/Michigan State University, Flint, MI, USA.
Journal of Community Hospital Internal Medicine Perspectives
|November 9, 2022
Summary
Patients hospitalized for acute myocardial infarction (AMI) with COVID-19 face over five times higher in-hospital mortality risk. This risk remains significantly elevated even after adjusting for other health factors, highlighting COVID-19
Area of Science:
- Cardiology
- Infectious Diseases
- Critical Care Medicine
Background:
- Patients hospitalized for acute myocardial infarction (AMI) may concurrently have coronavirus disease 2019 (COVID-19).
- The impact of COVID-19 on mortality risk in AMI patients requires further investigation.
Purpose of the Study:
- To compare the in-hospital mortality risk in patients hospitalized for AMI with versus without COVID-19.
Main Methods:
- Systematic review and meta-analysis of eight studies (December 2019 - April 2022) involving 10,128 patients.
- Utilized a random-effects model to pool data on in-hospital mortality.
- Conducted subgroup analysis for ST-elevation myocardial infarction (STEMI) and non-ST-segment elevation myocardial infarction (NSTEMI).
Main Results:
- Patients with AMI and COVID-19 had a significantly higher risk of in-hospital mortality (OR: 5.06).
- Adjusted analysis confirmed an over three times increased risk of mortality for AMI patients with COVID-19 (aOR: 3.47).
- NSTEMI patients with COVID-19 exhibited higher mortality risk compared to STEMI patients with COVID-19.
Conclusions:
- COVID-19 infection is independently associated with increased in-hospital mortality in patients hospitalized for AMI.
- The findings underscore the critical need for vigilant management and preventative strategies for AMI patients during the COVID-19 pandemic.
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