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Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
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Gastritis III: Clinical Manifestations and Management01:23

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The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
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Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
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Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

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Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
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[Ulcerative colitis complicated by pyoderma gangrenosum and multiple aseptic abscesses].

Aoi Kita1, Yu Hashimoto1, Keigo Sato1

  • 1Department of Gastroenterology and Hepatology, Gunma University Graduate School of Medicine.

Nihon Shokakibyo Gakkai Zasshi = the Japanese Journal of Gastro-Enterology
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A rare case of aseptic abscesses in the lungs and kidneys associated with ulcerative colitis (UC) and pyoderma gangrenosum (PG) was successfully treated with enhanced immunosuppression, including increased prednisolone and infliximab.

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Area of Science:

  • Gastroenterology
  • Dermatology
  • Immunology

Context:

  • Ulcerative colitis (UC) and pyoderma gangrenosum (PG) are chronic inflammatory conditions.
  • Aseptic abscesses, characterized by neutrophil infiltration without infection, are rare complications.
  • This case highlights a unique presentation of aseptic abscesses in deep organs associated with UC and PG.

Purpose:

  • To report a rare case of aseptic abscesses in the lungs and kidneys in a patient with ulcerative colitis and pyoderma gangrenosum.
  • To discuss the diagnostic challenges and treatment strategies for UC-associated aseptic abscesses.
  • To emphasize the importance of considering aseptic abscesses in patients with UC and PG presenting with unexplained abscesses.

Summary:

  • A woman with ulcerative colitis and pyoderma gangrenosum developed multiple lung and kidney abscesses.
  • Initial treatment with antibiotics and granulocyte/monocyte apheresis was ineffective.
  • Enhanced immunosuppression with increased prednisolone and infliximab led to significant improvement and abscess resolution.

Impact:

  • This case expands the known spectrum of aseptic abscess manifestations in inflammatory bowel disease.
  • It underscores the potential benefit of intensified immunosuppressive therapy in managing severe, refractory cases.
  • The findings suggest that aseptic abscesses should be considered in the differential diagnosis of abscesses in patients with UC and PG, guiding appropriate treatment strategies.