Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Working Memory01:24

Working Memory

413
Working memory refers to a combination of components, including short-term memory and attention, that allow an individual to hold information temporarily as we perform cognitive tasks. It is an essential cognitive function that enables the execution of complex tasks such as problem-solving, comprehension, and reasoning. Unlike short-term memory, which simply involves the storage of information for a brief period, working memory involves the active manipulation and processing of this...
413
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

350
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
350
Role of Cerebellum and Prefrontal Cortex in Memory01:14

Role of Cerebellum and Prefrontal Cortex in Memory

554
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
554

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bioenergetic dysregulation in the basal ganglia and cerebellum of patients with premanifest and manifest Huntington's disease.

Neurobiology of disease·2026
Same author

Striatal hyperechogenicity as an ultrasound imaging marker for prodromal X-linked dystonia-parkinsonism.

NPJ Parkinson's disease·2026
Same author

Identification and Enrollment of Individuals Prior to Parkinson's Disease Diagnosis: Biomarker-Driven Adaptive Eligibility and Enrollment into the Parkinson's Progression Markers Initiative.

Annals of neurology·2026
Same author

Reply to Geber and Birklein: A mechanistic perspective on offset analgesia and spatial summation of pain in polyneuropathy.

Pain·2026
Same author

Phenotypic spectrum of FGF14-related late-onset ataxia: predominant tremor and cognitive decline as key features of SCA27A.

Journal of neurology·2026
Same author

Genetic Testing by Age at Onset in Parkinson Disease.

JAMA neurology·2026
Same journal

Auditory event-related potentials and psychosis dimensions.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026
Same journal

Cultural humility in the teaching and practice of clinical care.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026
Same journal

Kappa opioid receptors mediate aversion-and it matters.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026
Same journal

Splice isoforms of the histone variant macroH2A1 differentially regulate hippocampal gene expression and memory formation.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026
Same journal

Chronic ethanol self-administration alters dopamine in the caudate nucleus and putamen of rhesus macaques in a sex-dependent manner.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026
Same journal

In memoriam-Shigeto Yamawaki, M.D., Ph.D. (1954-2026).

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026
See all related articles

Related Experiment Video

Updated: Aug 22, 2025

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents
09:01

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents

Published on: July 8, 2015

12.7K

Pramipexole modulates fronto-subthalamic pathway in sequential working memory.

Marcus Heldmann1,2, Eliana Mönch1, Antonia Kesseböhmer1

  • 1Department of Neurology, University of Lübeck, Lübeck, 23538, Germany.

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
|November 9, 2022
PubMed
Summary
This summary is machine-generated.

Dopamine D2/3 receptor agonist pramipexole impairs sequential working memory by altering fronto-subthalamic pathway activity. This suggests dopamine D2 transmission regulates sequential memory via this pathway.

More Related Videos

Author Spotlight: Combined Peripheral Nerve Stimulation and Controllable Pulse Parameter Transcranial Magnetic Stimulation to Probe Sensorimotor Control and Learning
14:47

Author Spotlight: Combined Peripheral Nerve Stimulation and Controllable Pulse Parameter Transcranial Magnetic Stimulation to Probe Sensorimotor Control and Learning

Published on: April 21, 2023

2.9K
Automated, Long-term Behavioral Assay for Cognitive Functions in Multiple Genetic Models of Alzheimer's Disease, Using IntelliCage
06:46

Automated, Long-term Behavioral Assay for Cognitive Functions in Multiple Genetic Models of Alzheimer's Disease, Using IntelliCage

Published on: August 4, 2018

12.3K

Related Experiment Videos

Last Updated: Aug 22, 2025

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents
09:01

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents

Published on: July 8, 2015

12.7K
Author Spotlight: Combined Peripheral Nerve Stimulation and Controllable Pulse Parameter Transcranial Magnetic Stimulation to Probe Sensorimotor Control and Learning
14:47

Author Spotlight: Combined Peripheral Nerve Stimulation and Controllable Pulse Parameter Transcranial Magnetic Stimulation to Probe Sensorimotor Control and Learning

Published on: April 21, 2023

2.9K
Automated, Long-term Behavioral Assay for Cognitive Functions in Multiple Genetic Models of Alzheimer's Disease, Using IntelliCage
06:46

Automated, Long-term Behavioral Assay for Cognitive Functions in Multiple Genetic Models of Alzheimer's Disease, Using IntelliCage

Published on: August 4, 2018

12.3K

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Pharmacology

Background:

  • Dopamine's role in sequential working memory is not fully understood.
  • Sequential working memory involves maintaining and manipulating ordered information.
  • Dopamine D2/3 receptors are implicated in cognitive functions.

Purpose of the Study:

  • To investigate how the dopamine D2/3 receptor agonist pramipexole affects fronto-subthalamic and fronto-striatal pathways during sequential working memory.
  • To clarify the role of dopamine D2 transmission in sequential working memory.

Main Methods:

  • Double-blind, randomized crossover study with 22 healthy male volunteers.
  • Pharmacological functional magnetic resonance imaging (fMRI) during a digit ordering task.
  • Administration of pramipexole (0.5-mg) or placebo, with analysis of performance, regional activity, pattern similarity, and functional connectivity.

Main Results:

  • Pramipexole impaired digit ordering task performance (accuracy and speed).
  • It downregulated subthalamic and dorsolateral prefrontal activity for maintenance but upregulated it for manipulation.
  • Altered dorsolateral prefrontal activity pattern similarity and fronto-subthalamic functional connectivity were observed.

Conclusions:

  • The fronto-subthalamic pathway is crucial for sequential working memory.
  • Dopamine D2 transmission modulates sequential working memory by regulating the fronto-subthalamic pathway.
  • Pramipexole's effects highlight the complex role of dopamine in cognitive control.