Related Experiment Video
Updated: Aug 22, 2025

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease
Published on: August 9, 2024
User's guide to sample size estimation in diagnostic accuracy studies
1Department of Emergency Medicine, Marmara University School of Medicine, Istanbul, Turkey.
Accurate sample size estimation is crucial for diagnostic accuracy studies but often overlooked. This guide provides practical methods and tools for researchers to determine appropriate sample sizes for diagnostic tests with dichotomized outcomes.
Area of Science:
- Medical Research Methodology
- Diagnostic Test Evaluation
Background:
- Sample size estimation is frequently neglected in diagnostic accuracy studies.
- Clinical researchers often lack guidance on sample size determination for diagnostic tests.
Purpose of the Study:
- To provide clear procedures for sample size estimation in diagnostic accuracy studies.
- To offer practical guidance and tools for researchers to determine appropriate sample sizes.
Main Methods:
- Detailed explanation of sample size estimation procedures for dichotomized outcomes.
- Inclusion of clinically relevant examples and practical tables.
- Development of a free online sample size calculator.
Main Results:
- Researchers can estimate sample sizes without complex calculations.
- The review serves as a practical guide for sample size determination.
- Accessible tools are provided to simplify the estimation process.
Conclusions:
- Improved sample size estimation in diagnostic accuracy studies is achievable.
- The provided resources empower researchers to conduct more robust studies.
- This work aims to enhance the quality of diagnostic accuracy research through better sample size planning.
More Related Videos
12:18A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
Published on: January 11, 2020
09:00Author Spotlight: Validation of SICOLE-R for Assessing Cognitive and Reading Skills in Spanish-Speaking Children and Its Role in Personalized Education
Published on: August 16, 2024
Related Concept Videos
Sample Size Calculation
The sample size for the given experiment or sampling effort is fundamental to any study design. Sample size decides the number of...
Accuracy and Errors in Hypothesis Testing
In hypothesis testing, the probability of making a Type I error, denoted as α, is commonly set at 0.05. This significance level indicates a 5%...
Contaminants and Errors
Another key consideration is determining the appropriate number of samples required to...
Estimating Population Mean with Unknown Standard Deviation
William S. Gosset (1876–1937) of the...
Sensitivity, Specificity, and Predicted Value
Sensitivity is the...
Receiver Operating Characteristic Plot